Scientist, Structural Biology

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Scientist, Structural Biology

BMS is a leader in the discovery and development of novel therapies that exploit targeted protein degradation. Structural biology is critical to our protein homeostasis (PH) research. High-quality 3D structures of proteins and protein complexes involved in Ubiquitin/Proteasome System-mediated degradation enable our scientists to understand mechanisms of action, design ligands or drug molecules, and make predictions about new biological targets for our drug discovery efforts. A deep focus in Oncology puts our resources squarely on projects of intense biomedical interest.

The successful candidate will perform and direct research within a talented group of structural biologists and will focus their experience and expertise in the PH field. There is opportunity to have a real-time, high-value impact on the ongoing projects as well as chart the future of our research efforts by capitalizing on structural insights, for example by uncovering mechanisms of action, defining binding modes, and identifying target degrons. The scientist will collaborate closely with chemistry, biology, proteomics, and computer-aided drug design scientists to advance our PH drug discovery projects. We are seeking a passionate scientist who strives to bring impactful structural biology insights to bear on a burgeoning portfolio of PH targets, with the goal of bringing novel therapies to patients. This is an on-site laboratory-based role.

Job Responsibilities

• Plan, execute, and report on experimental studies resulting in novel structures for CRBN E3 Ligase Modulators (CELMoDs) and Ligand Directed Degraders (LDDs) using crystallographic and cryo-EM methods
• Lead structural biology efforts pursuing novel ligands for ubiquitin ligases and other PH targets, including experimental sample preparation and structural determination
• Represent the Structural Biology team at project level meetings, and experimentally support multiple projects in parallel

Basic Qualifications

Bachelor's Degree with 5+ years of academic or industry experience

or

Master’s Degree with 3+ years of academic or industry experience,

or

Ph.D. with 0 years of academic or industry experience

Preferred Qualifications

• Ph.D. with 1+ years of industry experience
• Candidates with significant drug discovery experience in an industrial setting will be given preference
• Training and prior experience in X-ray crystallography and/or single-particle cryo-electron microscopy for the elucidation of protein structure
• A strong understanding of protein biochemistry and ability to troubleshoot protein behavior, crystallization and/or sample preparation for cryo-EM
• In-depth knowledge of current practices, instrumentation, software and issues for answering key structural biology questions with a focus on enzymes and large protein complexes
• Demonstrated hands-on experience in protein construct design, protein expression, and protein purification
• A record of scientific publication employing the skills listed above
• Strong written and oral communication skills to clearly deliver scientific results and presentations
• Demonstrated ability to thrive as part of a multidisciplinary team and inspire mutually beneficial collaborations to drive the development of PH therapeutics

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

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